ChemInform Abstract: Total Synthesis of Non-Natural Compounds for Molecular Recognition: The Double Challenge

Autor:	Amalia Galán, C. Seel, Armando Salmerón, J. De Mendoza, Enrique Botana, Guo-Yuan Lu, Pilar Prados, J. O. Magrans, J. Sanchez-Quesada, Marta Martı́n-Portugués, Victoria Alcázar, Margarita Segura
Rok vydání:	2010
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Molecular recognition chemistry Bicyclic molecule Stereochemistry Biomolecule Total synthesis Molecule General Medicine Guanidine Transition state Phosphocholine
Zdroj:	ChemInform. 28
ISSN:	0931-7597
Popis:	Molecular recognition of biomolecules by synthetic receptors requires modular assembly of various components to complement the molecular characteristics (sizes, topologies, and functional groups) of the substrate. A number of receptors for biorelevant molecules containing oxoanions have been assembled from a bicyclic chiral guanidine subunit. Several receptors accelerate or catalyze reactions proceeding through anionic transition states. Among the structures recently prepared, a receptor incorporating a calix(6)arene subunit has been developed, showing high affhity for phosphocholine derivatives. Chains of tetraguanidinium sulfates form double helices in solution. These substances strongly induce formation of a-helical conformations in Asp rich peptides.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::775a78665f4edfe938fa1de3c5bb27e7 https://doi.org/10.1002/chin.199730285 Zobrazit plný text záznamu Plný text