Combined directed ortho-metalation, remote metalation, and Stille cross-coupling strategies. Concise stereoselective synthesis of polysubstituted 9H-fluoren-9-ones

Autor:	Anne-Sophie Castanet, David Tilly, Jacques Mortier, Subhendu S. Samanta, Asish De, Jean-Baptiste Veron, Tapan Ganguly
Rok vydání:	2008
Předmět:	Metalation Chemistry Organic Chemistry Drug Discovery Organic chemistry Stereoselectivity Biochemistry Combinatorial chemistry Directed ortho metalation Stille reaction
Zdroj:	Tetrahedron. 64:3331-3336
ISSN:	0040-4020
Popis:	The new sequential stereoselective synthesis of diversely substituted 9H-fluoren-9-ones by ortho-lithiation/Bu3SnCl quench of unprotected benzoic acids followed by Stille cross-coupling reaction and remote metalation is reported.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::775878483aee51fd0695eba9ec85b202 https://doi.org/10.1016/j.tet.2008.01.122 Zobrazit plný text záznamu Full Text from ScienceDirect