Safety and efficacy of palonosetron compared in prevention of postoperative nausea and vomiting in patients undergoing elective major surgery under general anaesthesia

Autor:	Neha Godre, Mirza Shiraz Baig
Rok vydání:	2019
Předmět:	medicine.medical_specialty business.industry Palonosetron medicine In patient General anaesthesia medicine.symptom business Postoperative nausea and vomiting medicine.drug Surgery
Zdroj:	International Journal of Basic & Clinical Pharmacology. 8:2578
ISSN:	2279-0780 2319-2003
DOI:	10.18203/2319-2003.ijbcp20195260
Popis:	Background: Post-operative nausea and vomiting continues to be a common side effect of surgery and anaesthesia, affecting the economics of medical care, as well as the degree of patients’ satisfaction, comfort and quality of life.The objective of the present study were to compare the efficacy and safety of palonosetron versus placebo for prophylaxis of early onset (within 24 hours post-surgery) and late onset (24-72 hours post-surgery) post-operative nausea or vomiting in patients undergoing elective major surgery under general anaesthesia.Methods: A prospective, randomized, parallel group, two arm, double blind placebo controlled trial was conducted on n=100 indoor patients undergoing elective major surgeries were enrolled into the present study.Results: The patients showing complete response were 32 (64%) in palonosetron group and 19 (38%) in the placebo group (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7753853b1ab3c45023f27709917ff894 https://doi.org/10.18203/2319-2003.ijbcp20195260 Zobrazit plný text záznamu