Obstructive apnea/hypopia syndrome and non-alcoholic fatty liver disease: the role of hypoxia

Autor:	O. V. Korotchenko, O. Y. Gridnyev
Rok vydání:	2020
Předmět:	medicine.medical_specialty business.industry Fatty liver Disease medicine.disease Obesity Gastroenterology respiratory tract diseases Obstructive sleep apnea Diabetes mellitus Internal medicine Nonalcoholic fatty liver disease medicine Metabolic syndrome business Hypopnea
Zdroj:	Ukrainian Therapeutical Journal. :61-66
ISSN:	2522-1175 1605-7295
DOI:	10.30978/utj2020-3-61
Popis:	Sleep disorders is one of the topical issues of our times, affecting about half of the adult population. It has been determined that the most common sleep problems are obstructive sleep apnea/hypopnea syndrome — according to the WHO, its prevalence is comparable to the prevalence of diabetes. The data on the prevalence of obstructive sleep apnea/hypopnea syndrome in patients with metabolic syndrome are presented. Attention is drawn to the importance of overweight and obesity in the occurrence of obstructive sleep apnea/hypopnea syndrome and their relationship with the severity of the latter. The main mechanisms of obstructive sleep apnea/hypopnea sleep syndrome in obesity and the main links in the pathogenesis of progression of non-alcoholic fatty liver disease are described. The role of oxidative stress in the occurrence of inflammation and liver fibrosis is emphasized. The role of hypoxia in the pathogenesis of progression of nonalcoholic fatty liver disease in its combination with obstructive sleep apnea/hypopnea syndrome and its correlation with inflammatory and fibrosing processes has been shown. The unique place of a liver in a homeostasis of oxygen in an organism is noted. The history of the discovery and distribution of the family of hypoxia-induced factors is described. It is emphasized that all alpha subunits of the GIF complex act simultaneously, affecting both common and different molecular targets, which causes their special biological effects. The role of hypoxia-induced factors in the regulation of various processes in the body is shown. The advantage of studying hypoxia-induced factor-2a in the combined course of obstructive sleep apnea/hypopnea syndrome and non-alcoholic fatty liver disease is substantiated. The role of hypoxia-induced factor-2 alpha in the development and progression of nonalcoholic fatty liver disease has been shown.
Databáze:	OpenAIRE
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