Pyrimidine N-oxides. V. Ionization constants of N-hydroxybarbiturates

Autor:	Hans Stünzi, William B. Cowden, Noel W. Jacobsen
Rok vydání:	1982
Předmět:	chemistry.chemical_compound Reaction mechanism Pyrimidine chemistry Ab initio quantum chemistry methods Biocatalysis Ionization Physical chemistry General Chemistry Crystal structure Mass spectrometry Macromolecule
Zdroj:	Australian Journal of Chemistry. 35:1251
ISSN:	0004-9425
DOI:	10.1071/ch9821251
Popis:	The ionization constants, pKa, of a number of N-hydroxy 5-substituted barbituric acids and their O-and N-alkylated derivatives are reported. For practical comparisons under physiological conditions, pKa values were also determined at I 0.15 M KNO3 and 37� for the clinically useful barbiturates metharbital, phenobarbital and veronal, and for their mono-N-hydroxy derivatives. The pKa values for N,N?-dihydroxyphenobarbital and the corresponding veronal were also measured.
Databáze:	OpenAIRE
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