association of diabetes and obesity with severity of dengue fever
| Autor: | Sidra Noureen, Adil Abbas, Mehboob Alam, Maria Bibi, Muhammad Wajahat, Dur-e-Shahwar Dur-e-Shahwar, Ijaz Ahmad, Usama Ahmed, Afifa Tanveer, Sabrina Sajjad, Mehtab Khurshid, Shah Zeb |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | International journal of health sciences. :6778-6794 |
| ISSN: | 2550-696X 2550-6978 |
| DOI: | 10.53730/ijhs.v6ns8.13999 |
| Popis: | The arboviral infection dengue represents a global public health risk as the frequency of cases climbs across period and is anticipated to do so in the future. The fundamental mechanisms behind the concept between obesity and dengue, however, are rarely discussed. A number of variables, including the existence of cytokines that increase inflammatory response and deregulation of endothelium barrier protein production, contribute to plasma permeability, a defining feature of severe dengue. The key diabetes-related variables that impact endothelium functioning include th-1 skewed responses and the production of junctional-related proteins. Additionally, obesity affects lipid metabolism and the immune system, which increases viral multiplication and inflammatory processes. The common factor among individuals with diabetes and obesity is chronic inflammation, which results in endothelial dysfunction. Explored along with the disease's relationships with diabetes and obesity are the potential causes of comorbidities in severe dengue. |
| Databáze: | OpenAIRE |
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