Polyacetylenes and Flavonoids Isolated from Flowers of Carthamus tinctorius
| Autor: | Thi Men Ngo, Thao Quyen Cao, Jeong Ah Kim, Byung Sun Min, Thi Oanh Vu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Interleukin 2
biology Carthamus Plant Science General Chemistry biology.organism_classification Jurkat cells General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Acetylene chemistry Biochemistry Enzymatic hydrolysis medicine Anti allergy Two-dimensional nuclear magnetic resonance spectroscopy medicine.drug |
| Zdroj: | Chemistry of Natural Compounds. 57:635-640 |
| ISSN: | 1573-8388 0009-3130 |
| DOI: | 10.1007/s10600-021-03439-2 |
| Popis: | A new acetylene, (8S)-deca-4,6-diyne-1,8-di-O-β-D-glucopyranoside (4), and four known polyacetylenes (1–3 and 5), together with nine known flavonoids (6–14), were isolated from the flowers of Carthamus tinctorius L. The structures of the isolates were elucidated by using spectroscopic analysis, mainly 1D and 2D NMR, HR-MS, and comparison with literature data, as well as enzymatic hydrolysis and Mosher′s esterification methods. All isolated compounds were evaluated for their anti-allergic effects by analyzing the inhibition of interleukin-2 (IL-2) expression in Jurkat T cells. Among them, 6-hydroxykaempferol 3,6-diglucoside (7) inhibited IL-2 production in activated T cells. |
| Databáze: | OpenAIRE |
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