Effect of prostacycline on the cerebral vessels and its pharmacological modulation
| Autor: | Akopov Se, Gabrielian Es, Balaian Bg |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
medicine.medical_specialty
Vascular smooth muscle Chemistry chemistry.chemical_element Prostacyclin General Medicine Human brain Calcium General Biochemistry Genetics and Molecular Biology Dipyridamole Contractility Endocrinology medicine.anatomical_structure Nifedipine Internal medicine cardiovascular system medicine Intracellular medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 102:1715-1718 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf00840805 |
| Popis: | The ability of prostacyclin to relax human brain arteries contracted by different vasotropic agents has been investigated. Prostacyclin relaxation effect was less marked in atherosclerotically damaged vessels. Nifedipine was demonstrated to potentiate relaxation effect of prostacyclin at the level of sarcolemmal calcium transport, while cavinton and dipyridamole had an analogous influence, redistributing calcium in the intracellular stores. The potentiating effect of these drugs was also less pronounced in affected vessels, which might be connected to the depression of transport ATPase activity in the vascular smooth muscle cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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