| Autor: |
Linda L. Stehlik, John V. Merriner |
| Rok vydání: |
1983 |
| Předmět: |
|
| Zdroj: |
Aquatic Toxicology. 3:345-358 |
| ISSN: |
0166-445X |
| DOI: |
10.1016/0166-445x(83)90015-2 |
| Popis: |
Juvenile spot were administered Kepone ® (chlordecone) by ingestion. Body burdens of Kepone increased additively and equilibrium was not attained. When spot were fed a lethal concentration (3.3 μg/g) over 28 days, they accumulated an average of 2.7 μg/g (wet wt). Most of them developed muscular tetany, fractured vertebral centra, and abnormally thickened vertebrae. These symptoms developed over a 4-wk period until death. Spot fed lesser concentrations (0.59 and 0.30 μg/g) accumulated 0.7 and 0.3 μg/g over 56 days and developed similar bone damage. The percentage of collagen in vertebrae was significantly greater in the treated fish which had thickened bones. Spot that were held in the laboratory as controls for 5 wk had significantly lower collagen percentages than wild fish. These results confirm Kepone accumulation as the likely mechanism for production of the bone deformities observed in fishes from the James River in 1971–1976. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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