Mutation Profile of pfdhfr and pfdhps in Plasmodium falciparum among Returned Chinese Migrant Workers from Africa
| Autor: | Kun Yin, Qingkuan Wei, Gong-zhen Liu, Chao Xu, Long-jiang Wang, Xiangli Kong, Jin Li, Guihua Zhao, Hui Sun, Ge Yan, Ting Xiao, Bingcheng Huang, Yongbin Wang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pharmacology Mutation Veterinary medicine High prevalence biology Migrant workers 030231 tropical medicine Plasmodium falciparum Baseline data biology.organism_classification medicine.disease_cause medicine.disease Resistant genotype 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Infectious Diseases parasitic diseases Genotype medicine Pharmacology (medical) Malaria |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 63 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.01927-18 |
| Popis: | We evaluated markers of sulfadoxine-pyrimethamine (SP) resistance in Plasmodium falciparum among 254 returned migrant workers in China from Africa from 2013 to 2016. High prevalences of pfdhfr (97.2%) and pfdhps (96.5%) mutations were observed. The partially resistant genotype was homogeneously distributed in Africa with a modestly high prevalence (48%), whereas the super resistant genotype was only found in West Africa with a very low frequency (1.2%). The findings provided baseline data about the molecular markers of SP resistance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|