Syntheses and Evaluation of Some Mannich Bases Derived from Acetophenones Against P38 8 Lymphocytic Leukemia and Toxicological Assessment of 3-Dimethylamino-2-dimethylaminomethyl- 1 -(4-methoxypheny1)- 1 -Propanone Dihydrochloride in Rats

Autor:	P. J. Smith, B. M. Cross, Krishnamurthy Shyam, B. M. Logan, Jonathan R. Dimmock
Rok vydání:	1984
Předmět:	chemistry.chemical_classification Chemistry medicine.drug_class Stereochemistry Pharmaceutical Science Biological activity Mannich base Pharmacology medicine.disease medicine.disease_cause Haloketone Aminoketone Leukemia chemistry.chemical_compound Toxicity medicine Irritation Aliphatic compound
Zdroj:	Journal of Pharmaceutical Sciences. 73:471-477
ISSN:	0022-3549
DOI:	10.1002/jps.2600730411
Popis:	A number of analogues of 3-dimethylamino-2-dimethylaminomethyl-1-(4-methoxyphenyl)-1-propanone dihydrochloride (IIa) and related compounds which showed activity against P388 lymphocytic leukemia were prepared, and of the 16 analogues, three met the criterion for activity in this screen. The toxicity of IIa was examined in rats and either a single dose of 25 mg/kg or nine daily doses of 12.5 mg/kg administered by the intra-peritoneal route produced marked irritation and damage to the tissue with which it came into contact. Compound IIa did not show significant activity against eight other tumor systems.
Databáze:	OpenAIRE
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