| Autor: |
I. Petö, G. Sas, D. Bánhegyi |
| Rok vydání: |
1979 |
| Předmět: |
|
| Zdroj: |
Thrombosis and Haemostasis. |
| ISSN: |
2567-689X |
| DOI: |
10.1055/s-0039-1684713 |
| Popis: |
We found a new thrombophilic family with antithrombin III/ AT-III / deficiency. In the members of this family both immunologic and functional methods revealed similarly decreased levels of AT-III. Gelfiltration displayed identical size of AT-III molecule of patient and normal alike. On the basis of tnese findings we assumed that in this family normal AT-III is produced Dut only in diminished quantity. Experiments on the heparin-affinity of AT-III did not support this assumption. The AT-III of the proposita migrated slower than that of normal person in the heparinized agarose gel. In the course of the heparin-affinity chromatography the AT-III of the proposita could be eluted at lower salt concentrations than normal AT-III.Thus we conclude that even in the case of “true” AT-III deficiency the molecule might have some qualitative deviation from normal. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
