Clinical and immunological features of very long-term survivors with a single renal transplant
| Autor: | L Bererhi, Christophe Legendre, Dany Anglicheau, Sophie Candon, Nicolas Pallet, Henri Kreis, Julien Zuber |
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| Rok vydání: | 2012 |
| Předmět: |
Transplantation
medicine.medical_specialty Creatinine Naive T cell business.industry medicine.medical_treatment Cancer Immunosuppression medicine.disease Gastroenterology Immunosurveillance chemistry.chemical_compound Immune system chemistry Internal medicine Immunology medicine business Kidney transplantation |
| Zdroj: | Transplant International. 25:545-554 |
| ISSN: | 0934-0874 |
| Popis: | Summary The aim of this study was to analyze the clinical and immunological features of the 56 still alive patients at our institution harboring a functional first renal transplant since more than 30 years. The mean post-transplant graft survival in all patients was 35.4 ± 3.1 years, the mean serum creatinine concentration was 128.7 ± 7 μmol/l, and the mean urinary protein concentration was 0.6 ± 0.5 g/l. Fifty-one percent of the patients had experienced cancer involving the skin (46.1%) and/or other tissues (28%). Hepatocarcinoma was diagnosed in 11% of the patients with chronic viral hepatitis B and/or C (48%). The 5-year patient survival rate (considered after the 30th transplantation anniversary) was 27% in patients presenting a tumor versus 87% in those tumor-free (P |
| Databáze: | OpenAIRE |
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