Comparing bromocriptine effects with levodopa effects on bladder function in Parkinson's disease
| Autor: | M Chiharu Yamaguchi, Tatsuya Yamamoto, Yoshinori Higuchi, Takashi Ito, Makoto Kobayashi, Ryuji Sakakibara, Satoshi Kuwabara, Takamichi Hattori, Masashi Yano, Mitsuru Yanagisawa, Tomoyuki Uchiyama, Tomohiko Ichikawa, Yusuke Awa, Tomonori Yamanishi |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Levodopa Urinary bladder Urinary urgency business.industry Urinary system Urology Decarboxylase inhibitor urologic and male genital diseases medicine.disease Bromocriptine Central nervous system disease Bladder outlet obstruction Endocrinology medicine.anatomical_structure Neurology Internal medicine medicine Neurology (clinical) medicine.symptom business medicine.drug |
| Zdroj: | Movement Disorders. 24:2386-2390 |
| ISSN: | 0885-3185 |
| Popis: | To evaluate the effects of bromocriptine on bladder function in Parkinson's disease (PD) patients and compare these effects with those of (L-dopa). We recruited 8 patients with PD. Urodynamic study (UDS) was performed before and 1 hour after administering 100 mg L-dopa/decarboxylase inhibitor (DCI) and 2.5 hours after administering 7.5 mg bromocriptine. After the bromocriptine administration, urinary urgency aggravated. UDS revealed a decreased bladder volume at which detrusor overactivity (DO) was initiated, a decreased bladder volume at first sensation of bladder filling (FSV) (P < 0.05), an increased maximum Watts Factor value (WFmax) (detrusor contractility), a decreased Abrams-Griffiths (AG) number (urethral obstruction), and a decreased postvoid residual (PVR) (P < 0.01). Similarly, after the L-dopa administration, urinary urgency aggravated. UDS revealed an aggravated DO (P < 0.05), a decreased FSV and bladder capacity (P < 0.01, 0.05), an increased WFmax (P < 0.05), an increased AG number, and a decreased PVR (P < 0.01). A single dose of bromocriptine proved to exacerbate urinary urgency and DO in the storage phase, and improve bladder emptying through increased detrusor contractility and decreased bladder outlet obstruction, within hours. With the exception of bladder outlet obstruction, these effects of bromocriptine are similar to the effects of L-dopa, albeit slightly less pronounced. © 2009 Movement Disorder Society |
| Databáze: | OpenAIRE |
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