Clindamycin vasculitis in patients with peripheral arterial vascular disease

Autor:	G. B. Stark, Jamil Al-Jamali, Khalid Al-awadi, Gunther Felmerer, Ziad Kalash, Ahmed Kasem
Rok vydání:	2009
Předmět:	medicine.medical_specialty Pathology Vascular disease business.industry Cutis Clindamycin Pseudomembranous colitis medicine.disease Dermatology Rash Lincomycin Necrotizing Vasculitis medicine Surgery medicine.symptom Vasculitis business medicine.drug
Zdroj:	European Journal of Plastic Surgery. 32:267-269
ISSN:	1435-0130 0930-343X
Popis:	Clindamycin was first synthesized in 1966. It is a chemical derivative of lincomycin with activity against aerobic gram-positive and gram-negative bacteria. The side effects include diarrhea, pseudomembranous colitis, metallic taste in the mouth, transient elevation of transaminases, granulocytopenia, thrombocytopenia, and rash. The incidence of maculopapular rashes has been reported to be approximately 10%. Leukocytoclastic angitis or vasculitis induced by clindamycin has been reported (Lambert et al., Cutis 30:615–619, 1982) and this is a very serious complication in patients with peripheral arterial vascular diseases which may leads to severe and deep necrotizing vasculitis. We report two cases of necrotizing vasculitis due to clindamycin which was used for the treatment of chronic wounds in patients suffering of peripheral vascular disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::77063e07846ea80baafda6891b586d25 https://doi.org/10.1007/s00238-009-0343-6 Zobrazit plný text záznamu Full text from SpringerLink