Single molecule study of DNA collision with elliptical nanoposts conveyed by hydrodynamics
| Autor: | Yannick Viero, Marc Fouet, Aurélien Bancaud, Qihao He |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Physics
Field (physics) media_common.quotation_subject 010401 analytical chemistry Clinical Biochemistry Dynamics (mechanics) 02 engineering and technology Mechanics 021001 nanoscience & nanotechnology Collision 01 natural sciences Biochemistry Asymmetry 0104 chemical sciences Analytical Chemistry Nanolithography Brownian dynamics Molecule 0210 nano-technology media_common Nanopillar |
| Zdroj: | ELECTROPHORESIS. 34:3300-3304 |
| ISSN: | 0173-0835 |
| DOI: | 10.1002/elps.201300354 |
| Popis: | Periodic arrays of micro- or nanopillars constitute solid-state matrices with excellent properties for DNA size separation. Nanofabrication technologies offer many solutions to tailor the geometry of obstacle arrays, yet most studies have been conducted with cylinders arranged in hexagonal lattices. In this report, we investigate the dynamics of single DNA collision with elliptical nanoposts using hydrodynamic actuation. Our data show that the asymmetry of the obstacles has minor effect on unhooking dynamics, and thus confirm recent predictions obtained by Brownian dynamics simulations. In addition, we show that the disengagement dynamics are correctly predicted by models of electrophoresis, and propose that this consistency is associated to the confinement in slit-like channels. We finally conclude that elliptical posts are expected to marginally improve the performances of separation devices. |
| Databáze: | OpenAIRE |
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