Osteoporosis in inflammatory bowel disease: effect of calcium and vitamin D with or without fluoride

Autor:	Jean-Yves Mary, J.L. Dupas, Stanislas Chaussade, Vered Abitbol, C. Roux, Jacques Belaiche, Jean-Pierre Gendre, Soulé Jc, Eric Lerebours
Rok vydání:	2002
Předmět:	Bone mineral Vitamin medicine.medical_specialty Hepatology Bone disease business.industry Osteoporosis Gastroenterology chemistry.chemical_element Calcium Placebo medicine.disease Inflammatory bowel disease chemistry.chemical_compound Endocrinology chemistry Internal medicine Vitamin D and neurology medicine Pharmacology (medical) business
Zdroj:	Alimentary Pharmacology & Therapeutics. 16:919-927
ISSN:	0269-2813
DOI:	10.1046/j.1365-2036.2002.01247.x
Popis:	Background: Previous data have indicated low bone formation as a mechanism of osteoporosis in inflammatory bowel disease. Fluoride can stimulate bone formation. Aim: To assess the effect of fluoride supplementation on lumbar spine bone mineral density in osteoporotic patients with inflammatory bowel disease treated in parallel with calcium and vitamin D. Methods: In this prospective, randomized, double-blind, parallel and placebo-controlled study, 94 patients with inflammatory bowel disease (lumbar spine T score below − 2 standard deviations, normal serum 25OH vitamin D), with a median age of 35 years, were included. Bone mineral density was measured by dual-energy X-ray absorptiometry. Patients were randomized to receive daily either sodium monofluorophosphate (150 mg, n=45) or placebo (n=49) for 1 year, and all received calcium (1 g) and vitamin D (800 IU). The relative change in bone mineral density from 0 to 12 months was tested in each group (fluoride or placebo) and compared between the groups. Results: Lumbar spine bone mineral density increased significantly in both groups after 1 year: 4.8 ± 5.6% (n=29) and 3.2 ± 3.8% (n=31) in the calcium–vitamin D–fluoride and calcium–vitamin D–placebo groups, respectively (P
Databáze:	OpenAIRE
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