The incidence of low-level HER2 gene amplification and chromosome 17 polysomy in cases of newly diagnosed breast cancer and their association with clinical prognostic markers

Autor:	Anthony D. Elias, D. Melancon, K. Swisshelm, C. I. O'Donnell, Loris McGavran, Jennifer R. Diamond, Virginia F. Borges, M. Singh, R. Amaria, L. Meltesen
Rok vydání:	2009
Předmět:	Oncology Cancer Research Polysomy medicine.medical_specialty Pathology business.industry Incidence (epidemiology) Newly diagnosed medicine.disease Chromosome 17 (human) Breast cancer Internal medicine HER2 Gene Amplification Medicine skin and connective tissue diseases business
Zdroj:	Journal of Clinical Oncology. 27:e22012-e22012
ISSN:	1527-7755 0732-183X
DOI:	10.1200/jco.2009.27.15_suppl.e22012
Popis:	e22012 Background: The purpose of this study is to describe the frequency of low level HER2 gene amplification and chromosome 17 polysomy, and its association with known clinical prognostic markers. Methods: We retrospectively reviewed all cases of newly diagnosed invasive breast cancer referred to the Colorado Cytogenetic laboratory for FISH testing from either the University of Colorado Breast Center or St. Mary's Hospital in Grand Junction, CO between October 2000 and May 2005, excluding patients treated with HER2-directed therapy. Cases were classified into positive for HER2 gene amplification (FISH ratio ≥ 2.2), negative for HER2 gene amplification (FISH ratio [Table: see text] No significant financial relationships to disclose.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::76f1756be602d64d52b30f12d06e13c3 https://doi.org/10.1200/jco.2009.27.15_suppl.e22012 Zobrazit plný text záznamu