Synthesis of Propargyl Compounds and Their Cytotoxic Activity

Autor:	P. M. Quan, V. T. Ha, N. D. Luyen, L. Phong, Ngo Van Tai, L. H. Cuong, H. K. Chi, L. V. Chinh
Rok vydání:	2021
Předmět:	HeLa biology 010405 organic chemistry Cell culture Stereochemistry Chemistry Organic Chemistry Propargyl Cytotoxic T cell biology.organism_classification 01 natural sciences 0104 chemical sciences
Zdroj:	Russian Journal of Organic Chemistry. 57:462-468
ISSN:	1608-3393 1070-4280
DOI:	10.1134/s1070428021030192
Popis:	Twelve compounds bearing one or two propargyl groups were prepared and screened for their cytotoxic activity. Three derivatives, 3-methyl-1-(prop-2-yn-1-yloxy)-9H-carbazole, 1,3-dihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-6-(prop-2-yn-1-yloxy)xanthen-9-one, and (3E,7E,11E)-3,7,10,10-tetramethyl-1-(prop-2-yn-1-yl)-1-azacyclododeca-3,7,11-trien-2-one, were found to have cytotoxic activity. Among them, 1,3-dihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-6-(prop-2-yn-1-yloxy)xanthen-9-one showed the strongest activity against HepG2, LU-1, and Hela cell lines with IC50 values of 1.02, 2.19, and 2.55 μg/mL, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::76e84bd310208a1900eb9a2c03f3f4d4 https://doi.org/10.1134/s1070428021030192 Zobrazit plný text záznamu Plný text ve formátu PDF