Color and Luminance Contrast Sensitivity Changes in Early- and Late-Onset Strabismic Amblyopia

Autor: AR Davis, John J. Sloper, Michael J. Morgan, M.M. Neveu, Chris Hogg, Graham E. Holder
Rok vydání: 2006
Předmět:
Zdroj: Journal of American Association for Pediatric Ophthalmology and Strabismus. 10:81
ISSN: 1091-8531
DOI: 10.1016/j.jaapos.2006.01.125
Popis: and Late-Onset Strabismic Amblyopia John J. Sloper, Alison R. Davis, Majella M. Neveu, Chris R. Hogg, Michael J. Morgan, Graham E. Holder; Moorfields Eye Hospital, London, UK Purpose: Studies in nonhuman primates indicate that monocular visual deprivation starting at different ages has different effects on the parvocellular and magnocellular pathways. The present study has used color and luminance contrast sensitivity (CS) measurements to examine this question in human strabismic amblyopes. Methods: Contrast sensitivity was measured to a 3.2-cpd red-green isoluminant grating with a slow onset ramp and an achromatic 0.8-cpd grating with rapid onset ramp using a staircase method. Fifteen earlyand 14 late-onset strabismic amblyopes with similar ranges of visual acuity and 15 normal subjects were studied. Results: Both luminance and color CS were lower in the amblyopic than fellow eyes of all amblyopes. For luminance CS this was as much due to an increase in sensitivity of the fellow eye as a reduction in the amblyopic eye. Color CS was greatly reduced in both the amblyopic and the fellow eyes of both earlyand late-onset strabismic amblyopes compared to normal. The reduction of color CS compared to luminance CS calculated as (Luminance CS Color CS)/Luminance CS was significantly greater in latethan early-onset amblyopes (P 0.034; unpaired t-test). Conclusions: Parvocellularand magnocellular-related CS are differentially affected in both the amblyopic and the fellow eyes of strabismic amblyopes. The difference is more marked in amblyopes of late onset.
Databáze: OpenAIRE
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