Greater α1-adrenergic-mediated vasoconstriction in contracting skeletal muscle of patients with type 2 diabetes
| Autor: | Satoshi Hanada, Nicholas T. Kruse, Andrew J. Feider, Joshua M. Bock, Darren P. Casey, Kenichi Ueda, Erika Iwamoto, William E. Hughes |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Adrenergic receptor Physiology business.industry Type 2 Diabetes Mellitus Skeletal muscle Adrenergic Vasodilation Type 2 diabetes medicine.disease Endocrinology medicine.anatomical_structure Physiology (medical) Internal medicine Diabetes mellitus medicine medicine.symptom Cardiology and Cardiovascular Medicine business Vasoconstriction |
| Zdroj: | American Journal of Physiology-Heart and Circulatory Physiology. 319:H797-H807 |
| ISSN: | 1522-1539 0363-6135 |
| DOI: | 10.1152/ajpheart.00532.2020 |
| Popis: | Findings presented in this article are the first to show patients with type 2 diabetes mellitus have blunted hyperemic and vasodilatory responses to dynamic handgrip exercise. Moreover, we illustrate greater α1-adrenergic-mediated vasoconstriction may contribute to our initial observations. Collectively, these data suggest patients with type 2 diabetes may have impaired functional sympatholysis, which can contribute to their reduced exercise capacity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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