FRI0059 SARCOPENIA IN PATIENTS WITH RHEUMATOID ARTHRITIS

Autor: Emre Tekgöz, I. Sonaeren, Sedat Yilmaz, Muhammet Cinar, F. Ozalp, Seda Colak
Rok vydání: 2020
Předmět:
Zdroj: Annals of the Rheumatic Diseases. 79:606.2-606
ISSN: 1468-2060
0003-4967
DOI: 10.1136/annrheumdis-2020-eular.4863
Popis: Background:Sarcopenia is defined as the decrease in strength, mass and function of muscles and may be related with aging, chronic inflammation or malnutrition. Proinflammatory cytokines may be associated with development of sarcopenia.Objectives:The aim of this study was to evaluate sarcopenia in patients with Rheumatoid Arthritis (RA).Methods:One hundred patients with RA (30 Male/70 Female) and 100 healthy controls (30 Male/70 Female) were included in this cross sectional study. According to The European Working Group on Sarcopenia in Older People (EWGSOP2) 2018, three parameters; muscle strength, muscle mass and physical performance, which are evaluated by hand grip strength, Body Impedance Analyzer (BIA) and 6 meters gait speed test, respectively, are used to diagnose sarcopenia. Patients with arthritis in dominant hand joints and ankle joints were excluded. Sarcopenia is defined as the decrease of strength and mass of muscles. On the other hand patients with low muscle strength but normal muscle mass are defined as probable sarcopenia.Results:The mean age was 58.52±10.95 for patients and 56.62±10.08 for controls (p=0.203). Frequency of probable sarcopenia was 35 (35.0%) in RA and 9 (9.0%) in control group (p2=0.62) (Table 2).Table 1.Factors associated with sarcopenia in rheumatoid arthritisRheumatoid arthritis groupNo sarcopenia(n=65)Probable Sarcopenia(n=35)p-valueSex, n (%) Male24 (36.9)6 (17.1)0.04a Female41 (63.1)29 (82.9)Age*55.00 (25.00−82.00)63.00 (24.00−82.00)0.004bDisease duration (year)*4.00 (1.00−37.00)8.00 (1.00−41.00)0.037bDAS28 CRP*2.13 (1.08−4.69)2.55 (1.54−5.56)0.010bDAS28 ESR (mean±SD)2.63±0.943.36±1.00cCDAI*5 (0−25)9 (0−29)0.012bSDAI*5.09 (0.04−26.04)9.8 (0.39−31.7)0.006bHAQ*0.15 (0−1.05)0.4 (0−19.5)baPearson Chi-Square,bMann-Whitney U Test,cIndependent Samples t-Test. *Variables given as median (minimum-maximum) DAS: Disease activity score ESR:Erythrocyte sedimentation rate, CRP:C-reactive protein, CDAI: Clinical Disease Activity Index, SDAI: Simplified Disease Activity Index, HAQ: Health Assessmnet QuestionnaireTable 2.Multivariate analysis for hand grip test in patients with rheumatoid arthritisUnstandardized Coefficients95% CIStandardized Coefficientsp-valueBStd.ErrorLowerUpperBetaConstant53.653.8945.9361.37−Gender−13.061.41−15.86−10.26−0.60DAS28 CRP−3.210.70−4.61−1.82−0.29Age−0.220.06−0.33−0.10−0.23DAS: Disease activity score CRP:C-reactive proteinConclusion:Loss of muscle strength in patients with RA may be seen frequently. Longer disease duration and higher disease activity should lead to development of sarcopenia due to chronic inflammation. Sarcopenia potentially effects patients’ social lives and daily functions and conceive decrease quality of life. Physicians should be aware of development of sarcopenia during the course of the disease, and take into account the preservative and preventive methods against to sarcopenia including exercise and control of disease activity.Acknowledgments:None to declareDisclosure of Interests:None declared
Databáze: OpenAIRE
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