Autophagy Induction by HDAC Inhibitors Is Unlikely to be the Mechanism of Efficacy in Prevention of Retinal Degeneration Caused by P23H Rhodopsin
| Autor: | Orson L. Moritz, Ruanne Y.J. Vent-Schmidt, Aaron D Loewen, Runxia H. Wen |
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| Rok vydání: | 2019 |
| Předmět: |
Retinal degeneration
Valproic Acid genetic structures biology medicine.drug_class Chemistry Histone deacetylase inhibitor Autophagy Xenopus medicine.disease biology.organism_classification Cell biology 03 medical and health sciences 0302 clinical medicine Rhodopsin Retinitis pigmentosa medicine biology.protein lipids (amino acids peptides and proteins) sense organs 030212 general & internal medicine Histone deacetylase medicine.drug |
| Zdroj: | Retinal Degenerative Diseases ISBN: 9783030273774 |
| DOI: | 10.1007/978-3-030-27378-1_66 |
| Popis: | We previously found that valproic acid (VPA) and other histone deacetylase inhibitors (HDACis) ameliorate retinal degeneration (RD) caused by P23H rhodopsin in Xenopus laevis larvae and hypothesized that this may be due to enhancement of autophagy. Here we use X. laevis expressing an autophagy marker to assess effects of HDACis on autophagy. We also assess the effects of non-HDACi activators and inducers of autophagy on RD caused by P23H rhodopsin. |
| Databáze: | OpenAIRE |
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