Effect of pomegranate extract on vagina, skeleton, metabolic and endocrine profiles in an ovariectomized rat model
| Autor: | Işık Kaban, Aysun Fendal Tunca, Fugen Akar, Nurettin Aka, Alpaslan Kaban, Hacer Kavak |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Triglyceride Bone density business.industry Osteoporosis Obstetrics and Gynecology 030209 endocrinology & metabolism medicine.disease Menopause 03 medical and health sciences chemistry.chemical_compound Follicle-stimulating hormone 0302 clinical medicine Endocrinology medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Internal medicine medicine Ovariectomized rat Vagina Vaginal atrophy business |
| Zdroj: | Journal of Obstetrics and Gynaecology Research. 44:1087-1091 |
| ISSN: | 1341-8076 |
| Popis: | AIM Many women need estrogen therapy because of menopausal complaints. It is suggested that pomegranate plant has estrogenic effect. Aim of the study was to examine the effects of pomegranate seed extract on menopausal changes. METHODS This study was conducted in an experimental environment with 23 Wistar Albino genus female rats. Sixteen rats were divided into two groups after ovariectomy. One group (SG) was fed with standard food and the pomegranate extract was added to drinking water of the other group (PG). Seven rats were identified as the sham group for the detection of basal values. At the end of 90 days, follicle stimulating hormone (FSH), estradiol, total cholesterol, high-density lipoprotein cholesterol (HDL)-cholesterol, low-density lipoprotein cholesterol (LDL)-cholesterol, triglyceride, tibial bone cortex thickness and vaginal epithelium thickness of the groups were compared. RESULTS FSH, total-cholesterol and HDL-cholesterol levels were similar among the three groups (P > 0.05), while others were different (P < 0.05). In binary comparisons (PG vs SG), estradiol level (average ± standard deviation [SD]: 252 ± 43 vs 154 ± 26 pg/mL), tibial bone cortex thickness (58 ± 7 vs 40 ± 2 μm) and vaginal epithelium thickness (21 ± 7 vs 10 ± 4 μm) were significantly higher in PG. In PG, triglyceride levels (103 ± 26 vs 87 ± 41 mg/dL) were higher and LDL-cholesterol levels were lower (20 ± 8 vs 27 ± 8 mg/dL), but these differences were not significant. CONCLUSION In rats fed with pomegranate extract, estradiol levels increased and tibial bone cortex thickness and vaginal epithelium thickness also increased. Pomegranate itself or its formulation extracts may be a support or an alternative to the main treatment modalities in the preservation of bone density and the treatment of vaginal epithelial atrophy. |
| Databáze: | OpenAIRE |
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