Design, synthesis and molecular docking studies of some 1-(5-(2-fluoro-5-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-3-yl)piperazine derivatives as potential anti-inflammatory agents
| Autor: | Muthipeedika Nibin Joy, Ranjith Pakkath, B. Kulkarni, K. Manjunatha, Ayyiliath Meleveetil Sajith, Mohammed B. Alshammari, C. N. Prashantha |
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| Rok vydání: | 2021 |
| Předmět: |
Activity profile
medicine.drug_class Organic Chemistry Oxadiazole General Medicine Diclofenac Sodium Combinatorial chemistry Catalysis Anti-inflammatory Inorganic Chemistry chemistry.chemical_compound Piperazine chemistry Design synthesis Drug Discovery medicine Molecule Physical and Theoretical Chemistry Molecular Biology Reference standards Information Systems |
| Zdroj: | Molecular Diversity. 26:2893-2905 |
| ISSN: | 1573-501X 1381-1991 |
| Popis: | We herein report the facile synthesis of a series of 3,5-substituted-1,2,4-oxadiazole derivatives in good to excellent yields. The anti-inflammatory potential of the newly synthesized compounds was evaluated by anti-denaturation assay using diclofenac sodium as the reference standard. Some of the compounds exhibited profound activity profile when compared to the standard drug. The molecular docking and SAR studies were carried out at the later stage for gaining more insights about the promising activity profile of the synthesized molecules. |
| Databáze: | OpenAIRE |
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