| Popis: |
Female rats were given oleic acid, erucic acid, ethyl oleate, ethyl erucate, triolein and trierucin by oral intubation for 4 days (3 g/kg/day) and drug-metabolizing enzymes were investigated. A significant increase in liver microsomal enzymes occured after erucic acid treatment. Ethyl erucate and triolen exerted a stimulatory effect only on certain enzymes whereas oleic acid, ethyl oleate and trierucin had no effect. These changes were associated with significant modifications in DNA, RNA and protein content of the rat liver and of the hepatic fraction containing microsomes. The data indicated that erucic acid acted as a potent inducer of microsomal enzymes and suggested that this acid was a “foreign” compound. |
