Inhibition and regulation of antioxidant protection, microsomal oxidation, and xenobiotic glucuronidation in cholestatic rats
| Autor: | T. I. Khomich, M. I. Bushma, V. E. Karpovich, L. M. Karaedova, L. K. Lashak, O. V. Konovalenko, L. F. Legon'kova, I. V. Zverinskii |
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| Rok vydání: | 1999 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Antioxidant biology Chemistry Bilirubin medicine.medical_treatment Glutathione peroxidase Glucuronidation General Medicine Essentiale General Biochemistry Genetics and Molecular Biology Superoxide dismutase chemistry.chemical_compound Endocrinology Catalase Internal medicine biology.protein medicine Xenobiotic glucuronidation |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 127:176-179 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf02433107 |
| Popis: | An 8-day biliary obstruction in rats caused by ligation of the common bile duct is accompanied by an increase in bilirubin blood content and alanine aminotransferase activity. The hepatic xenobiotic-metabolizing activity (intensities of microsomal oxidation and glucuronidation) decreases in parallel with the inhibition of antioxidant enzymes (catalase, superoxide dismutase, and glutathione peroxidase). A comparative study of Heptral, Ursofalk, Essentiale, and Cordiamin (nikethamide) showed that Cordiamin displays the most significant enzymestabilizing activity. |
| Databáze: | OpenAIRE |
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