Immune Paralysis Induced by Pneumococcal Polysaccharide
| Autor: | William G. Wu, Finn O. Horve, Carole C. Williams |
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| Rok vydání: | 1971 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 107:154-162 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.107.1.154 |
| Popis: | The phagocytic and antibody-inductive activity of peritoneal cells (PC) derived from mice immunized or immunologically paralyzed with capsular antigen of Diplococcus pneumoniae type III (SIII) was studied. In vitro exposure of PC from “paralyzed” animals to 32P-labeled bacteria indicated that their rate of phagocytosis was similar to that of controls. Cells from immune animals showed an increased uptake of organisms, this being attributed to cell-associated antibody. When studied by passive cell transfer procedures in normal recipients, PC from “paralyzed” and immune animals conferred protection against challenge with viable organisms. Data obtained from irradiated recipients indicated that PC were necessary for production of antibody by spleen cells. Furthermore, immune paralysis appeared to be disrupted by macrophages through an active process resulting in antibody production by formerly unresponsive cells. |
| Databáze: | OpenAIRE |
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