The role of hCG in endometrial receptivity and embryo implantation
| Autor: | Jemma Evans |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
endocrine system
Pregnancy urogenital system business.industry Receptivity Embryo medicine.disease Urinary hCG Endometrium Andrology Future study medicine.anatomical_structure Medicine Endometrial receptivity business reproductive and urinary physiology hormones hormone substitutes and hormone antagonists |
| DOI: | 10.1016/b978-0-12-820050-6.00014-x |
| Popis: | The role of hCG and specific hCG isoforms in human endometrial receptivity and embryo implantation is difficult to define. A large number of in vitro and in vivo studies conducted in primates and humans strongly suggest a role for hCG in endometrial receptivity. However, the findings of these studies have not translated to clinical studies where the efficacy of intrauterine hCG delivery has not supported benefit on pregnancy outcome, this may be partially due to suboptimal study design. The scene is further complicated when the source of hCG is taken into account. Studies have variously used urinary hCG preparations, which are known to be contaminated with growth factors, or recombinant hCG, which is representative of one form of hCG only. The characterization of a hyperglycosylated form of hCG which accounts for up to 40% of hCG released by hatched blastocysts has never been directly investigated for its role in endometrial receptivity and embryo implantation. What then is the true impact of hCG in the endometrium with respect to receptivity? This chapter will summarize current knowledge and highlight avenues for future study in this area. |
| Databáze: | OpenAIRE |
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