IL-6, IL-8 and IL-10 polymorphisms may impact predisposition of Alzheimer’s disease: a meta-analysis

Autor: Rongmei Yang, Chenling Hu, Jinfeng Duan, Fugang Luo, Pingyu Tao
Rok vydání: 2020
Předmět:
Zdroj: Acta Neurologica Belgica. 121:1505-1512
ISSN: 2240-2993
0300-9009
DOI: 10.1007/s13760-020-01369-4
Popis: Gene polymorphisms in interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-10 (IL-10) may affect the predisposition of Alzheimer’s disease (AD), but the results of the so far published studies remain controversial. The authors conducted this meta-analysis to assess relationships between IL-6/IL-8/IL-10 polymorphisms and predisposition of AD by pooling the findings of so far published studies. A comprehensive search of Pubmed, Embase, Web of Science, and CNKI was endorsed by the authors to identify the already published studies. Forty-five studies were found to be eligible for meta-analyses. The pooled meta-analyses results showed that genotypic frequencies of IL-6 − 174 G/C, IL-6 − 572 G/C and IL-10 − 1082 A/G polymorphisms among patients with AD and controls differed significantly. Moreover, genotypic frequencies of IL-6 − 174 G/C, IL-6 − 572 G/C, and IL-8 − 251 A/T polymorphisms among patients with AD and controls in Asians also differed significantly. But no such genotypic frequencies’ differences were observed for IL-10 − 819 C/T and 592 C/A polymorphisms. This meta-analysis suggests that IL-6 − 174 G/C, IL-6 − 572 G/C, and IL-10 − 1082 A/G polymorphisms may affect the predisposition of AD in overall population. Moreover, IL-6 − 174 G/C, IL-6 − 572 G/C, and IL-8 − 251 A/T polymorphisms may affect the predisposition of AD in Asians.
Databáze: OpenAIRE
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