| Autor: |
Imran Hassan, Cary M. Looney, Analia Alvarez, Thomas Schindler, Elizabeth Zuta Santillán, J Garg, Richard Furie, Brad H. Rovin, Hilda Fragoso-Loyo, Gustavo Aroca, Paul Brunetta, Ana Malvar, Matthew D Cascino |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Oral presentations. |
| Popis: |
Background Previous analyses identified associations between the degree of B-cell depletion and response in lupus nephritis (LN). NOBILITY tested whether enhanced B-cell depletion with the type II anti-CD20 mAb obinutuzumab could improve responses in LN. Methods 126 patients with active Class III/IV LN were randomized to obinutuzumab or placebo infusions in combination with mycophenolate and corticosteroids. Peripheral B-cells were measured using a flow cytometry method with a lower limit of 0.441 cells/μL. Sustained depletion was assessed by flow cytometry measurements at weeks 24 and 52. Results Obinutuzumab was associated with increased CRR (40% vs. 18%, P=0.007) and ORR (51% vs. 29%, P =0.015) at week 76. Obinutuzumab resulted in rapid and complete depletion of peripheral B-cells, memory and naive B-cell subsets, and plasmablasts, with 89% of obinutuzumab patients depleted to Conclusions Obinutuzumab, a type II anti-CD20 mAb, induced rapid and complete depletion of peripheral B-cells and B-cell subsets. Similar to previous reports, sustained B-cell depletion was associated with increased renal response. Further evaluation is ongoing to understand the factors associated with achievement of sustained B-cell depletion and renal response. Acknowledgements This study was funded by F. Hoffmann-La Roche. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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