Dynamics of changes in specific hypersensitivity and of the nonspecific increase in sensitivity to endotoxin in BCG-sensitized mice

Autor: O. Vejbora, J. Johanovský, M. Vrána
Rok vydání: 1961
Předmět:
Zdroj: Folia Microbiologica. 6:370-378
ISSN: 1874-9356
0015-5632
DOI: 10.1007/bf02877178
Popis: (1) Quantitative changes in specific hypersensitivity and nonspecific sensitivity were studied at different intervals after sensitization in white mice sensitized with different doses of BCG vaccine. (2) Specific hypersensitivity was determined by the pad test, from the degree of swelling of the pad after the injection of 10 μg. PPD. Nonspecific sensitivity was determined from the percentage of deaths among mice to which 0.1 mg.Salmonella paratyphi B endotoxin was administered intravenously. (3) It was found that specific hypersensitivity reached maximum values two to four months after sensitization. Maximum nonspecific sensitivity to the effect of endotoxin occurred two to three weeks after sensitization. The size of the sensitization dose was directly proportionale to the increase in nonspecific sensitivity and was not directly related to the degree of specific hypersensitivity. (4) These results exclude the possibility that nonspecific sensitivity to endotoxin develops directly as a causal consequence of the delayed type of hypersensitivity and that it is one of the manifestations of this hypersensitivity. The findings are in agreement with the hypothesis that the change in sensitivity to endotoxin is the outcome of the summation of toxic stimuli formed during the hypersensitivity reaction of the cells with antigenin vivo.
Databáze: OpenAIRE
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