Synthesis of Phosphonobenzocarbacephems by Intramolecular Radical Cyclization of Haloaryl-Substituted β-Lactams
| Autor: | Sarah Van der Jeught, Christian V. Stevens, Kurt G. R. Masschelein |
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| Rok vydání: | 2010 |
| Předmět: |
Intramolecular reaction
Organic Chemistry Free-radical reaction Tributyltin hydride Chemical synthesis Radical cyclization Medicinal chemistry Dowd–Beckwith ring-expansion reaction chemistry.chemical_compound chemistry Intramolecular force Organic chemistry Staudinger reaction Physical and Theoretical Chemistry |
| Zdroj: | European Journal of Organic Chemistry. 2010:1333-1338 |
| ISSN: | 1099-0690 1434-193X |
| DOI: | 10.1002/ejoc.200901351 |
| Popis: | A series of benzo-fused tricyclic β-lactams, most of them phosphonobenzocarbacephems, were prepared in a straightforward way starting from phosphonoazadienes. In this paper, the synthetic route including a Staudinger reaction towards the β-lactams, followed by radical ring closing with tributyltin hydride and AIBN, which resulted in the envisaged tricyclic compounds, is reported. |
| Databáze: | OpenAIRE |
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