ChemInform Abstract: Copper Hydride-Catalyzed Tandem 1,4-Reduction/Alkylation Reactions

Autor:	Randall W. Vivian, Bruce H. Lipshutz, Joseph A. Sclafani, Kevin Noson, Will Chrisman, Patrick Papa, John M. Keith
Rok vydání:	2001
Předmět:	chemistry.chemical_classification chemistry.chemical_compound chemistry Silylation Copper hydride General Medicine Silyl enol ether Lewis acids and bases Alkylation Aldehyde Enone Medicinal chemistry Catalysis
Zdroj:	ChemInform. 32
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200114065
Popis:	Exposure of an enone to a catalytic quantity of [CuH(PPh3)]6 in the presence of one of several silyl hydrides (PhMe2SiH, PMHS, HMe2SiOSiMe2H) leads to conjugate reduction with concomitant formation of the corresponding silyl enol ether. Without isolation, treatment of these intermediates with a Lewis acid at low temperatures in the presence of an aldehyde, or with fluoride ion together with an activated halide, affords good yields of the product of 3-component coupling (3-CC) in a single reaction flask.
Databáze:	OpenAIRE
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