An improved synthesis of N-acetoxy-N-acetyl-2-aminofluorene-9-14C using an extractive acylation technique
| Autor: | W. P. Duncan, M. R. Thissen |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
chemistry.chemical_classification
Hydroxamic acid Organic Chemistry Salt (chemistry) Biochemistry Analytical Chemistry Acylation chemistry.chemical_compound Acetic anhydride chemistry Acetylation Yield (chemistry) Drug Discovery Organic chemistry Radiology Nuclear Medicine and imaging Ammonium Specific activity Spectroscopy |
| Zdroj: | Journal of Labelled Compounds and Radiopharmaceuticals. 15:59-64 |
| ISSN: | 0362-4803 |
| DOI: | 10.1002/jlcr.2580150109 |
| Popis: | A rapid, high yield (90–100%) method for the preparation of N-acetoxy-N-acetyl-2-aminofluorene-9-14C (N-AcO-AAF-9-14C) from N-hydroxy-N-acetyl-2-aminofluorene-9-14C (N-OH-AAF-9-14C) is described. The procedure consists of the in situ formation of a quaternary ammonium salt of N-OH-AAF-9-14C in a two-phase system and subsequent acetylation of this salt with acetic anhydride. The specific activity of the product was 40.6 mCi/mmole. |
| Databáze: | OpenAIRE |
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