Pharmacokinetics and drug interactions of medications used to treat hepatitis C virus infection in the setting of chronic kidney disease and kidney transplantation
| Autor: | Hirsh D. Trivedi, Claudia Nader, Guillermo Ortiz |
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| Rok vydání: | 2018 |
| Předmět: |
Drug
medicine.medical_specialty urogenital system business.industry medicine.medical_treatment media_common.quotation_subject Hepatitis C virus Hematology Hepatitis C medicine.disease medicine.disease_cause 03 medical and health sciences Regimen 0302 clinical medicine Nephrology Internal medicine medicine 030211 gastroenterology & hepatology 030212 general & internal medicine Hemodialysis Adverse effect business Kidney transplantation Kidney disease media_common |
| Zdroj: | Hemodialysis International. 22:S22-S35 |
| ISSN: | 1492-7535 |
| Popis: | Hepatitis C infection in patients with chronic kidney disease or kidney transplant carries higher morbidity and mortality compared to noninfected patients. Historically, patients with advanced kidney disease and kidney transplant recipients were undertreated given the multiple adverse effects and limited efficacy of interferon-based therapies for chronic hepatitis C. The development of direct-acting antivirals in the past few years has opened an unprecedented opportunity for treating these populations. However, the impaired renal clearance of some of these medications in patients with kidney disease, and the potential interactions of antiviral therapies with immunosuppressants after kidney transplantation, present some challenges in choosing the proper regimen. This review provides an overview of the essential pharmacokinetics and drug interactions of relevant antiviral therapies in the treatment of chronic hepatitis C in patients with advanced kidney disease and after kidney transplantation. |
| Databáze: | OpenAIRE |
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