ChemInform Abstract: Stereoselective Access to trans-2,5-Disubstituted Pyrrolidine Derivatives by Nucleophilic Addition to Bicyclic N-Acyliminium Ion

Autor:	C. Vanucci, H. Dhimane, Gérard Lhommet
Rok vydání:	2010
Předmět:	chemistry.chemical_compound Nucleophilic addition Bicyclic molecule Chemistry Stereoselectivity General Medicine Lewis acids and bases Medicinal chemistry Pyrrolidine Ion
Zdroj:	ChemInform. 28
ISSN:	0931-7597
DOI:	10.1002/chin.199724132
Popis:	5-Alkoxy-pyrroloxazolidin-3-ones 1 were stereoselectively prepared from (S)-pyroglutamic acid. Treatment of 1 with a Lewis acid generated in situ the N-acyliminium 2 , which was trapped by various π-nucleophiles leading selectively to trans pyrrolidine derivatives 3 .
Databáze:	OpenAIRE
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