How many genes encode cholinesterase in arthropods?
| Autor: | Francois Villatte, Till T. Bachmann |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Genetics
chemistry.chemical_classification Carbamate integumentary system biology Health Toxicology and Mutagenesis medicine.medical_treatment Single gene General Medicine ENCODE biology.organism_classification Acetylcholinesterase chemistry.chemical_compound Enzyme chemistry biology.protein medicine Drosophila melanogaster Agronomy and Crop Science Gene Cholinesterase |
| Zdroj: | Pesticide Biochemistry and Physiology. 73:122-129 |
| ISSN: | 0048-3575 |
| DOI: | 10.1016/s0048-3575(02)00002-0 |
| Popis: | Carbamate and organophosphate pesticides act by inhibiting the key enzyme acetylcholinesterase in arthropods. Conversely to the case in vertebrates, in which two genes encode two different cholinesterases (ChE) a single gene was found in the fruit fly Drosophila melanogaster. In this species, several mutations decreasing the enzyme sensitivity to insecticides and thus responsible for resistance have been identified. After the sequencing of ChE-like genes in other species, repeated attempts to identify resistance mutations failed. These intriguing results raise the question of the existence of several ChE-encoding genes in a Arthropoda. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect