Increased telomere size in sperm cells of mammals with long terminal (TTAGGG)n arrays

Autor:	Andrei O. Zalensky, Alexander Kozik, E M Bradbury
Rok vydání:	1998
Předmět:	Genetics Somatic cell Chromosome Context (language use) Cell Biology Biology Sperm Telomere Cell biology Meiosis Spermatogenesis Cell aging Developmental Biology
Zdroj:	Molecular Reproduction and Development. 51:98-104
ISSN:	1098-2795 1040-452X
DOI:	10.1002/(sici)1098-2795(199809)51:1<98::aid-mrd12>3.0.co;2-q
Popis:	An increase in the length of telomeres in human sperm compared to somatic cells has long been noted and considered within a popular hypothesis involving telomere shortening and cell aging. In the present study we determined telomere length in two species with long terminal TTAGGG arrays--bovine and porcine. Using several independent methods we demonstrate that the telomeres in the sperm of human, porcine and bovine are elongated by 69%, 24%, and 14%, respectively, in comparison with somatic tissues. Therefore, increased sperm telomere length is a feature preserved throughout mammalian evolution. The biological role of this phenomenon is discussed in the context of telomere functions in meiosis and fertilization.
Databáze:	OpenAIRE
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