A rabbit model of human familial, nonsyndromic unicoronal suture synostosis II. Intracranial contents, intracranial volume, and intracranial pressure

Autor: Michael I. Siegel, Gregory F. Cooper, Kapucu Lo, Mark P. Mooney, Anne M. Burrows, Wendy Fellows-Mayle, Kapucu Mr, Jason Dechant, Losken Hw, Timothy D. Smith
Rok vydání: 1998
Předmět:
Zdroj: Child's Nervous System. 14:247-255
ISSN: 1433-0350
0256-7040
DOI: 10.1007/s003810050220
Popis: This two-part study reviews data from a recently developed colony of New Zealand white rabbits with familial, nonsyndromic unilateral coronal suture synostosis, and this second part presents neuropathological findings and age-related changes in intracranial volume (ICV) and intracranial pressure (ICP) in 106 normal rabbits and 56 craniosynostotic rabbits from this colony. Brain morphology and anteroposterior length were described in 44 rabbit fetuses and perinates (27 normal; 17 synostosed). Middle meningeal artery patterns were qualitatively assessed from 2-D PCC MRI VENC scans and endocranial tracings from 15, 126-day-old rabbits (8 normal, 7 rabbits with unicoronal synostosis). Brain metabolism was evaluated by assessing 18F-FDG uptake with high-resolution PET scanning in 7, 25-day-old rabbits (3 normal, 4 with unicoronal or bicoronal synostosis). Intracranial contents and ICV were assessed using 3-D CT scanning of the skulls of 30 rabbits (20 normal,10 with unicoronal synostosis) at 42 and 126 days of age. Serial ICP data were collected from 66 rabbits (49 normal; 17 with unicoronal synostosis) at 25 and 42 days of age. ICP was assessed in the epidural space using a Codman NeuroMonitor microsensor transducer. Results revealed that cerebral cortex morphology was similar between normal and synostosed fetuses around the time of synostosis. Significantly (P
Databáze: OpenAIRE
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