New Validated Stability-Indicating RP-HPLC Method for The Determination of Docetaxel and Its Related Substances

Autor:	Mukthinuthalapati Mathrusri Annapurna, S. Hemchand, R. Ravi Chandra Babu
Rok vydání:	2019
Předmět:	Chromatography biology Chemistry biology.organism_classification Diluent chemistry.chemical_compound Acetic acid Docetaxel Taxus Forced degradation medicine Pharmacology (medical) Particle size Methanol Acetonitrile Pharmacology Toxicology and Pharmaceutics (miscellaneous) medicine.drug
Zdroj:	Research Journal of Pharmacy and Technology. 12:4165
ISSN:	0974-360X 0974-3618
Popis:	Docetaxel is used for the treatment of castration resistant prostate cancer. Docetaxel is a semi synthetic chemo therapeutic agent extracted from the leaves of Taxus baccata. Two process related substances and four impurities were separated and quantified using Sunfire C18 column (250 x 4.6 mm, 5µm particle size) on gradient mode (40 ± 5°C). A mixture of acetonitrile: 0.01 % Acetic acid was used as mobile phase and a mixture of acetonitrile: methanol (1:1, v/v) was used as diluent and the compounds were monitored at 230 nm. Forced degradation studies were performed and the method was validated as per ICH guidelines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::76420997f8ba409b71fbb2b9f6762d4c https://doi.org/10.5958/0974-360x.2019.00719.4 Zobrazit plný text záznamu