Non-typhoidal Salmonella serovars associated with invasive and non-invasive disease in the Lao People's Democratic Republic
| Autor: | Le Thi Phuong, Tu, Rattanavong, Sayaphet, Vongsouvath, Manivanh, Davong, Viengmon, Phu Huong Lan, Nguyen, Campbell, James I, Darton, Thomas C, Thwaites, Guy E, Newton, Paul N, Dance, David AB, Baker, Stephen |
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NTS
Adult Male Salmonella typhimurium Adolescent HIV Salmonella enterica Serogroup Antimicrobial susceptibility 3. Good health Young Adult Cross-Sectional Studies Salmonella enteritidis Lao Salmonella Infections Humans Female Bloodstream infections Africa South of the Sahara Non-typhoidal Salmonella |
| Popis: | BACKGROUND: Invasive non-typhoidal Salmonella (iNTS) disease is a well-described cause of mortality in children and human immunodeficiency virus (HIV)-infected adults in sub-Saharan Africa. Additionally, there is an ill-defined burden of iNTS disease in Southeast Asia. METHODS: Aiming to investigate the causative serovars of non-invasive and iNTS disease and their associated antimicrobial susceptibility profiles in the Lao People's Democratic Republic, we performed multilocus sequence typing and antimicrobial susceptibility profiling on 168 NTS (63 blood and 105 faecal) organisms isolated in Lao between 2000 and 2012. RESULTS: Six different serovars were isolated from blood; Salmonella enterica serovar Enteritidis (n=28), S. enterica serovar Typhimurium (n=19) and S. enterica serovar Choleraesuis (n=11) accounted for >90% (58/63) of the iNTS disease cases. In contrast, the isolates from diarrhoeal faeces were comprised of 18 different serovars, the mostly commonly identified being S. enterica Typhimurium (n=28), S. enterica Weltevreden (n=14) and S. enterica Stanley (n=15). S. enterica Enteritidis and S. enterica Choleraesuis were significantly more associated with systemic disease than diarrhoeal disease in this patient group (p |
| Databáze: | OpenAIRE |
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