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Objectives: Aripiprazole, is an atypical antipsychotic. It is recommended and primarily used in the treatment of schizophrenia and bipolar disorder and it undergoes extensive hepatic metabolism. The aim of the current study was to develop thin films of Ariprazole to avoid its hepatic metabolism. Methods: In the present research, five different rapidly dissolving films of Aripiprazole were prepared successfully by using different polymers by means of solvent casting method. The prepared films were evaluated for different parameters including thickness, mass uniformity, pH, folding endurance, drug content uniformity, cumulative percent release, in-vitro dissolution test and accelerated stability studies. Drug release kinetics of the films, the data obtained were fitted to various kinetic equations Results: The thicknesses of the films were ranged in between 0.15±0.14mm to 0.20±0.09mm and weight in the range 41.3±0.68 to 47.6±0.83mg. The disintegration time of the films were found to be from 19±0.48 to 24±0.52seconds. Formulation of batch F4 has shown maximum release 95.48% in 30 minutes. There was no significant change in appearance, pH, folding endurance, drug content, in vitro disintegration and percentage drug release during stability testing. Conclusion: Study concludes effective delivery of Aripiprazole in the form of fast dissolving thin films. On the basis of different evaluated parameters formulation of batch F4 was found to be optimum formulation. Peer Review History: Received 3 September 2017; Revised 28 September; Accepted 1 November, Available online 15 November 2017 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 6.5/10 Average Peer review marks at publication stage: 7.5/10 Reviewer(s) detail: Dr. Mohammed Abdel-Wahab Sayed Abourehab, Umm Al-Qura University; Makkah Al-Mukarramah, Saudi Arabia, mohawahab2002@yahoo.com Dr. Robert Tungadi, State University of Gorontalo, Indonesia, rtungadi@yahoo.com Similar Articles: FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF ANTIEPILEPTIC DRUG IN VITRO-IN VIVO BIO-EQUIVALENCE CORRELATION STUDY OF ATENOLOL, AND ITS BRANDS OF IMMEDIATE RELEASE TABLET UNDER BIO-WAIVER CONDITIONS |
