Total Syntheses of Variolin B and Deoxyvariolin B1

Autor:	David Fernandez, Gerardo Danelon, Abderaouf Ahaidar, Ignacio Manzanares, Carmen Cuevas, Mercedes Alvarez, Fernando Albericio, John A. Joule
Rok vydání:	2003
Předmět:	chemistry.chemical_compound Chemical coupling Pyrimidine Chemistry Variolin B Stereochemistry Organic Chemistry Cross reactions Total synthesis Ring (chemistry) Chemical synthesis
Zdroj:	The Journal of Organic Chemistry. 68:10020-10029
ISSN:	1520-6904 0022-3263
DOI:	10.1021/jo035332b
Popis:	Two alternative synthetic routes have been developed for the preparation of variolin B and deoxyvariolin B. The strategy is based on the preparation of the core tricyclic ring common to all variolins, pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine, followed by a palladium-catalyzed cross-coupling reaction to give the tetracyclic system.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::762dd561f7ead6c3e99f98de4c97175c https://doi.org/10.1021/jo035332b Zobrazit plný text záznamu