ChemInform Abstract: Synthesis and Structure Determination of the Adducts of the Potent Carcinogen 7,12-Dimethylbenz(a)anthracene and Deoxyribonucleosides Formed by Electrochemical Oxidation: Models for Metabolic Activation by One-Electron Oxidation

Autor:	N. V. S. RamaKrishna, Eleanor G. Rogan, Ercole L. Cavalieri, Michael L. Gross, Ryszard Jankowiak, Ronald L. Cerny, H. Jeong, G. Dolnikowski, Gerald J. Small
Rok vydání:	2010
Předmět:	Anthracene chemistry.chemical_compound Deoxyribonucleosides chemistry 7 12-Dimethylbenz[a]anthracene Nucleic acid Organic chemistry General Medicine Electrochemistry Medicinal chemistry Carcinogen Derivative (chemistry) Adduct
Zdroj:	ChemInform. 23
ISSN:	0931-7597
DOI:	10.1002/chin.199227269
Popis:	Anodic oxidation of 7,12-dimethylbenz[a]anthracene (7,12-DMBA) in the presence of dG yields four adducts and one oxygenated derivative of 7,12-DMBA: 7-methylbenz[a]anthracene (MBA)-12-CH 2 -C8dG (13%), 7-MBA-12-CH 2 -N7Gua (55%), 12-MBA-7-CH 2 -N7Gua (12%), 7-MBA-12-CH 2 -C8Gua (10%), and 7,12-(CH 2 OH) 2 -BA (10%). The first three are primary products of the electrochemical reaction, whereas the last two are secondary products
Databáze:	OpenAIRE
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