Mn(II), Co(II), Ni(II), and Cu(II) complexes of amino acid derived Schiff base ligand: Synthesis, characterization and in-vitro antibacterial investigations

Autor:	A. A. Aliyu, H. F. Babamale, W. A. Osunniran, A. O. Rajee, Joshua A. Obaleye, A. O. Sheriff, A Lawal, Misitura Lawal
Rok vydání:	2021
Předmět:	chemistry.chemical_classification Schiff base Ligand Infrared spectroscopy General Chemistry Medicinal chemistry Electron spectroscopy Amino acid Metal chemistry.chemical_compound chemistry visual_art Octahedral molecular geometry visual_art.visual_art_medium Antibacterial activity
Zdroj:	Bulletin of the Chemical Society of Ethiopia. 35:97-106
ISSN:	1726-801X 1011-3924
DOI:	10.4314/bcse.v35i1.8
Popis:	Four complexes of Mn(II), Co(II), Ni(II) and Cu(II) with Schiff base ligand (H3L) derived from 2-amino-3-methylbutanoic acid and acetylacetonate were synthesized. All complexes were characterized by elemental analysis, Fourier-transform infrared spectroscopy and electronic spectroscopy. The results confirmed the coordination of the ligand to metals in tridentate fashion via the hydroxyl oxygen, the azomethine nitrogen and the enolic acetylacetonate oxygen. Antimicrobial activities were established for all complexes, free ligand and ciprofloxacin for comparison. Both the ligand and its metal complexes were active against Gram-positive and negative bacterial strains. The Cu(II) complex, showed highest antibacterial activity among the complexes screened. Other complexes displayed considerable antibacterial activity. Octahedral geometry was proposed for the metal(II) complexes with the Schiff base. KEY WORDS: Schiff base, Amino acid, Metal Complexes, Antibacterial agents Bull. Chem. Soc. Ethiop. 2021, 35(1), 97-106. DOI: https://dx.doi.org/10.4314/bcse.v35i1.8
Databáze:	OpenAIRE
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