Synthesis and biological activity of fibrate-based acyl- and alkyl-phenoxyacetic methyl esters and 1,2-dihydroquinolines

Autor: Eva Ramón-Gallegos, Miguel A. Vázquez, Aarón Mendieta, María del Carmen Cruz-López, Catalina Rugerio-Escalona, Abraham Pucheta, Germán Chamorro-Cevallos, Alejandra Ramírez-Villalva, Francisco Delgado, Joaquín Tamariz, Liseth Romero, Fabiola Jiménez, Damian A. Madrigal, Carlos González-Romero, Alfonso Sequeda-Juárez, Omar Gómez-García, Leticia Garduño-Siciliano, Roberto I. Hernández-Benitez, Aydeé Fuentes-Benítes, Lourdes Villa-Tanaca, Blanca Rosales-Acosta, Julio López
Rok vydání: 2020
Předmět:
Zdroj: Medicinal Chemistry Research. 29:459-478
ISSN: 1554-8120
1054-2523
Popis: A series of highly potent antihyperlipidemic agents constituted by a fibrate-based structure was recently reported by our group, whose synthesis started from isovanillin derivatives. In the interest of evaluating the bioisosteric effect of the vanillin-based isomers on their antihyperlipidemic activity, the present study focuses on the synthesis of 5-acyl-1-phenoxyacetic methyl esters 5a–c and their saturated side-chain 5-alkyl-1-phenoxyacetates 6a–c. Their strong in vivo effect was associated with the inhibition of HMG-CoA reductase. Since 1,2-dihydroquinolines inhibit this enzyme, a series of such heterocycles (9a–d) was prepared by our efficient regioselective, one-step, solvent-free method. Apart from showing hypolipidemic activity in vivo, some of the compounds displayed antifungal, antioxidant and cytotoxic activity in vitro. The binding mode of four compounds at the active site of HMGRh was examined with docking simulations, observing an interaction with most of the amino acids targeted by simvastatin.
Databáze: OpenAIRE
Externí odkaz: