520: Value of the natriuretic peptide proANP as a prognostic marker in pediatric heart transplantation
| Autor: | C. Knosalla, Stephan Schubert, Brigitte Stiller, Felix Berger, Hans B. Lehmkuhl, Mathias Redlin, Julia Lemmer, Grit Heise, Roland Hetzer |
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| Rok vydání: | 2007 |
| Předmět: |
Pulmonary and Respiratory Medicine
Transplantation medicine.medical_specialty Leukopenia medicine.drug_class business.industry Lymphocyte medicine.medical_treatment Immunosuppression Gastroenterology Tacrolimus medicine.anatomical_structure Internal medicine White blood cell medicine Natriuretic peptide Surgery Platelet Hemoglobin medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Journal of Heart and Lung Transplantation. 26:S247 |
| ISSN: | 1053-2498 |
| DOI: | 10.1016/j.healun.2006.11.544 |
| Popis: | used as adjunctive therapy twice weekly for 4 weeks. Results: There were no acute complications and none of the patients suffered any serious infections (one patient had an enterococcal UTI requiring antibiotic therapy). All patients were lymphopenic prior to Campath-1H, with absolute lymphocyte counts of 32-100 cells/ l. At 3 months post-Campath-1H, the hemoglobin and platelet counts for all patients remained normal. White blood cell counts ranged from 11004000 cells/ l with absolute lymphocyte counts of 100-500 cells/ l. By 3 months post-treatment, fractional shortening significantly improved from 28.6 3.9% to 45.3 4.2% (p 0.05). Two patients have had repeat endomyocardial biopsies, each with ISHLT scores of 1A. Maintenance immunosuppression consists of tacrolimus and mycophenolate mofetil. Conclusions: Campath-1H was used with predictable side effects (e.g. leukopenia), but without significant morbidity. Resistant rejection may be mediated independent of T cells, offering a potential explanation for Campth-1H’s utility. Long term follow-up and further study is warranted, but this experience demonstrates that Campath-1H can be effective for the treatment of resistant rejection in pediatric heart transplant recipients. |
| Databáze: | OpenAIRE |
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