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The purpose of the study was to research informative biochemical, inflammatory and oxidative stress indicators after SARS-CoV2 infection in obesity. Methods. Forty people (37.0 8.9 years old) were examined after SARS-CV2 infection and twenty people (36.0 5.4 years old) who had no documented coronavirus infection during the pandemic. The antibody to SARS-CV2 level, biochemical and oxidative stress indicators were determined. The proteolysis was assessed by the trypsin and elastase-like proteases and α1-proteins inhibitor (α1-PI) activity. Results. All subjects, regardless the COVID-19 infection in the anamnesis, had antibodies to SARS-CoV2. We found the TNF increased content, the trypsin- and elastase-like proteases activity, the increased MDA concentration and decreased catalase activity compared with the retrospective control. The biochemical parameters did not differ significantly from the normal values. But levels of C-reactive protein were three times higher in those who were ill than who probably had the disease in asymptomatic form (not vaccinated). Elevated levels of antibodies were found in people in post-COVID with dermatological, neurological, gastroenterological, cardiological symptoms and shortness of breath. Overweight individuals had higher antibody titer to SARS-CoV2, increase in trypsin-like protease activity, and decrease in α1-PI activity than normal weight ones. An increase in the adipose tissue percentage correlates with a decrease in α1-PI activity. Obesity causes chronic inflammation and PI deficiency in the postoperative period. Conclusion. In the COVID long period, the trypsin-like, elastic-like proteases activity, MDA and oxidative modified proteins level increased. Overweight individuals had elevated SARS-CoV2 antibodies, trypsin-like protein activity, and decreased α1-PI activity. |
