Diabetes and pre-diabetes among household contacts of tuberculosis patients in India: is it time to screen them all?
| Autor: | S. V. B. Y. Shivakumar, P. Chandrasekaran, A. M. V. Kumar, M. Paradkar, K. Dhanasekaran, N. Suryavarshini, B. Thomas, R. Kohli, K. Thiruvengadam, V. Kulkarni, L. E. Hannah, G. N. Sivaramakrishnan, N. Pradhan, C. Dolla, A. Gupte, G. Ramachandran, A. DeLuca, S. Meshram, R. Bhardawaj, R. C. Bollinger, J. Golub, K. Selvaraj, N. Gupte, S. Swaminathan, V. Mave, A. Gupta, null for the CTRIUMPh-RePORT India Study Team |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine medicine.medical_specialty Tuberculosis Cross-sectional study business.industry 030106 microbiology Skin test medicine.disease 03 medical and health sciences 0302 clinical medicine Infectious Diseases Tuberculosis diagnosis Pre diabetes Diabetes mellitus Internal medicine medicine 030212 general & internal medicine Young adult business Body mass index |
| Zdroj: | The International Journal of Tuberculosis and Lung Disease. 22:686-694 |
| ISSN: | 1027-3719 |
| DOI: | 10.5588/ijtld.17.0598 |
| Popis: | Setting Pre-diabetes mellitus (pre-DM) and DM increase the risk of developing tuberculosis (TB). Screening contacts of TB patients for pre-DM/DM and linking them to care may mitigate the risk of developing TB and improve DM management. Objective To measure the prevalence of pre-DM/DM and associated factors among the adult household contacts (HHCs) of pulmonary TB patients. Methods Between August 2014 and May 2017, adult HHCs of newly diagnosed adult PTB patients in Pune and Chennai, India, had single blood samples tested for glycosylated haemoglobin (HbA1c) at enrolment. DM was defined as previously diagnosed, self-reported DM or HbA1c 6.5%, and pre-DM as HbA1c between 5.7% and 6.4%. Latent tuberculous infection (LTBI) was defined as a positive tuberculin skin test (5 mm induration) or QuantiFERON® Gold In-Tube (0.35 international units/ml). Results Of 652 adult HHCs, 175 (27%) had pre-DM and 64 (10%) had DM. Forty (64%) HHCs were newly diagnosed with DM and 48 (75%) had poor glycaemic control (HbA1c 7.0%). Sixty-eight (22%) pre-DM cases were aged 18-34 years. Age 35 years, body mass index 25 kg/m2, chronic disease and current tobacco smoking were significantly associated with DM among HHCs. Conclusions Adult HHCs of TB patients in India have a high prevalence of undiagnosed DM, pre-DM and LTBI, putting them at high risk for developing TB. Routine DM screening should be considered among all adult HHCs of TB. |
| Databáze: | OpenAIRE |
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